Publications
Explore our library of peer-reviewed research validating the FLASH effect
and our core accelerator technology.
General Reviews
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Ultra-high
dose rate electron beams and the FLASH effect: From preclinical evidence to a new
radiotherapy paradigm
Schüler E, Acharya M, Montay-Gruel P, et al. · Med Phys ·
2022
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Technological Basis for Clinical Trials in FLASH Radiation Therapy: A Review
Wu Y, No H, Breitkreutz DY, Mascia AE, Moeckli R, Bourhis J, Schüler E, Maxim PG, Loo BW. . Applied Radiation Oncology. 2021 July; 10(2):6-14
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Understanding high-dose, ultra-high dose rate, and spatially
fractionated radiation therapy
Griffin, R. J. et al. · Int J Radiat Oncol Biol Phys ·
2020
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Ultra-high
dose rate (FLASH) radiotherapy: Silver bullet or fool’s
gold?
Wilson, J. D. et al. · Frontiers in Oncology · 2020
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Physics
and biology of ultrahigh dose-rate (FLASH) radiotherapy: a
topical review
Esplen, N. M. et al. · Physics in Medicine and Biology ·
2020
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Novel radiation therapy paradigms and immunomodulation: Heresies and
hope
Dutt, S., Ahmed, M. M., Loo, B. W., Jr, & Strober, S · Seminars
in Radiation Oncology · 2020
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Flash Radiotherapy is (Finally) on the Way
Massachusetts General Hospital · Proto Magazine · 2020
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PHASER linac will translate FLASH radiotherapy to the
clinic
Freeman, T · Physics World · 2019
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FLASH
radiotherapy: Newsflash or flash in the pan?
Maxim, P. G., Keall, P., & Cai, J · Medical Physics · 2019
Flash Radiation Biology
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Real-time optical oximetry during FLASH radiotherapy using a
phosphorescent nanoprobe
Ha B, Liang K, Liu C, et al. · Radiother Oncol · 2022
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Design and validation of a dosimetric comparison scheme tailored for ultra-high dose-rate electron beams to support multicenter FLASH preclinical studies.
Jorge PG, Melemenidis S, Grilj V, Buchillier T, Manjappa R, Viswanathan V, Gondré M, Vozenin MC, Germond JF, Bochud F, Moeckli R, Limoli C, Skinner L, No HJ, Wu YF, Surucu M, Yu AS, Lau B, Wang J, Schüler E, Bush K, Graves EE, Maxim PG, Loo BW Jr, Bailat C. Radiother Oncol. 2022 Oct;175:203-209. doi: 10.1016/j.radonc.2022.08.023
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Design
and validation of a dosimetric comparison scheme tailored for
ultra-high dose-rate electron beams...
Jorge PG, Melemenidis S, Grilj V, et al. · Radiother Oncol ·
2022
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Bayesian
optimization to design a novel x-ray shaping device
Whelan B, Trovati S, Wang J, et al. · Med Phys · 2022
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Abdominopelvic FLASH Irradiation Improves PD-1 Immune Checkpoint
Inhibition in Preclinical Models of Ovarian Cancer
Eggold JT, Chow S, Melemenidis S, et al. · Mol Cancer Ther ·
2022
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Multicellular Spheroids as In Vitro Models of Oxygen Depletion During
FLASH Irradiation
Khan S, Bassenne M, Wang J, et al. · Int J Radiat Oncol Biol Phys
· 2021
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Effects of Ultra-high doserate FLASH Irradiation on the Tumor
Microenvironment in Lewis Lung Carcinoma...
Kim YE, Gwak SH, Hong BJ, et al. · Int J Radiat Oncol Biol Phys ·
2021
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An
automated optimization strategy to design collimator geometry for small field
radiation therapy systems
Wang J, Wang L, Maxim PG, Loo BW Jr · Phys Med Biol · 2021
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Effects of Ultra-high doserate FLASH Irradiation on the Tumor Microenvironment in Lewis Lung Carcinoma: Role of Myosin Light Chain.
Kim YE, Gwak SH, Hong BJ, Oh JM, Choi HS, Kim MS, Oh D, Lartey FM, Rafat M, Schüler E, Kim HS, von Eyben R, Weissman IL, Koch CJ, Maxim PG, Loo BW Jr, Ahn GO. Int J Radiat Oncol Biol Phys. 2021 Apr 1;109(5):1440-1453. doi: 10.1016/j.ijrobp.2020.11.012
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FLASH
irradiation results in reduced severe skin toxicity compared to
conventional-dose-rate irradiation
Soto, L. A. et al. · Radiation Research · 2020
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Evaluating
the reproducibility of mouse anatomy under rotation in a
custom immobilization device for conformal FLASH radiotherapy
Ko, R. B. et al. · Radiation Research · 2020
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Reduced cognitive deficits after FLASH irradiation of whole mouse
brain are associated with less hippocampal...
Simmons, D. A. et al. · Radiotherapy and Oncology · 2019
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PHASER: A platform for clinical translation of FLASH cancer
radiotherapy
Maxim, P. G., Tantawi, S. G., & Loo, B. W., Jr · Radiotherapy and
Oncology · 2019
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FLASH
irradiation enhances the therapeutic index of abdominal radiotherapy for the
treatment of ovarian cancer
Levy, K. et al. · bioRxiv · 2019
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Conical
beam geometry intensity-modulated radiation therapy
Schüler, E., Wang, L., Loo, B. W., Jr, & Maxim, P. G · Physics in
Medicine and Biology · 2019
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Very
high-energy electron (VHEE) beams in radiation therapy: treatment plan comparison
between VHEE, VMAT, and PPBS
Schüler, E., Eriksson, K., Hynning, E., et al. · Medical Physics
· 2017
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Thermal limits
on MV x-ray production by bremsstrahlung targets in the context of novel linear
accelerators
Wang, J., Trovati, S., Borchard, P. M., et al. · Medical Physics
· 2017
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Experimental platform for ultra-high dose rate FLASH irradiation of
small animals using a clinical linear accelerator
Schüler, E., Trovati, S., King, G., et al. · Int J Radiat Oncol
Biol Phys · 2017
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Assessment of the quality of very high-energy electron radiotherapy
planning
Palma, B. et al. · Radiotherapy and Oncology · 2016
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Treatment
planning for radiotherapy with very high-energy electron beams and comparison of
VHEE and VMAT plans
Bazalova-Carter, M. et al. · Medical Physics · 2015
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Optimization
of an on-board imaging system for extremely rapid radiation therapy
Cherry Kemmerling, E. M., Wu, M., Yang, H., et al. · Medical
Physics · 2015
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Comparison of
film measurements and Monte Carlo simulations of dose delivered with very
high-energy electron beams...
Bazalova-Carter, M. et al. · Medical Physics · 2015
Phaser Technology Development
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Bayesian optimization to design a novel x-ray shaping device.
Whelan B, Trovati S, Wang J, Fahrig R, Maxim PG, Hanuka A, Shumail M, Tantawi S, Merrick J, Perl J, Keall P, Loo BW Jr. Med Phys. 2022 Dec;49(12):7623-7637. doi: 10.1002/mp.15887
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An automated optimization strategy to design collimator geometry for small field radiation therapy systems.
Wang J, Wang L, Maxim PG, Loo BW Jr. Phys Med Biol. 2021 Apr 6;66(7). doi: 10.1088/1361-6560/abeba9
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Novel radiation therapy paradigms and immunomodulation: Heresies and
hope
Dutt, S., Ahmed, M. M., Loo, B. W., Jr, & Strober, S · Seminars
in Radiation Oncology · 2020
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https://doi.org/10.1667/RADE-20-00069.1
Breitkreutz, D. Y., Shumail, M., Bush, K. K., Tantawi, S. G., Maxim, P. G., & Loo, B. W., Jr, (2020). Initial steps towards a clinical FLASH radiotherapy system: Pediatric whole brain irradiation with 40 MeV electrons at FLASH dose rates. Radiation Research, 10.1667/RADE-20-00069.1. Advance online publication
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PHASER: A platform for clinical translation of FLASH cancer
radiotherapy
Maxim, P. G., Tantawi, S. G., & Loo, B. W., Jr · Radiotherapy and
Oncology · 2019
-
Conical
beam geometry intensity-modulated radiation therapy
Schüler, E., Wang, L., Loo, B. W., Jr, & Maxim, P. G · Physics in
Medicine and Biology · 2019
-
Very
high-energy electron (VHEE) beams in radiation therapy: treatment plan comparison
between VHEE, VMAT, and PPBS
Schüler, E., Eriksson, K., Hynning, E., et al. · Medical Physics
· 2017
-
Thermal limits
on MV x-ray production by bremsstrahlung targets in the context of novel linear
accelerators
Wang, J., Trovati, S., Borchard, P. M., et al. · Medical Physics
· 2017
-
Assessment of the quality of very high-energy electron radiotherapy
planning
Palma, B. et al. · Radiotherapy and Oncology · 2016
-
Treatment
planning for radiotherapy with very high-energy electron beams and comparison of
VHEE and VMAT plans
Bazalova-Carter, M. et al. · Medical Physics · 2015
-
Optimization
of an on-board imaging system for extremely rapid radiation therapy
Cherry Kemmerling, E. M., Wu, M., Yang, H., et al. · Medical
Physics · 2015
-
Comparison of
film measurements and Monte Carlo simulations of dose delivered with very
high-energy electron beams...
Bazalova-Carter, M. et al. · Medical Physics · 2015
Core Accelerator And Rf Power Research
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Design and demonstration of a distributed-coupling linear accelerator
structure
Tantawi, S. G., Nasr, M., Li, Z., et al. · Physical Review
Accelerators and Beams, 23(9) · 2020
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Development for a supercompact X-band pulse compression system and
its application at SLAC
Wang, J. W., Tantawi, S. G., Xu, C., et al. · Physical Review
Accelerators and Beams, 20(11) · 2017
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Compact RF polarizer and its application to pulse compression
systems
Franzi, M., Wang, J., Dolgashev, V., & Tantawi, S. G · Physical
Review Accelerators and Beams, 19 · 2016
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High-power multimode X-band RF pulse compression system for future
linear colliders
Tantawi, S. G., Nantista, C. D., Dolgashev, V. A., et al. ·
PRST-AB, 8(4) · 2005
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Multimoded RF delay line distribution system for the Next Linear
Collider
Tantawi, S. G., Nantista, C., Kroll, N., et al. · PRST-AB, 5(3) ·
2002
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A compact,
planar, eight-port waveguide power divider/combiner: the cross potent
superhybrid
Nantista, C., & Tantawi, S. G · IEEE Microwave and Guided Wave
Letters, 10 · 2000
