FLASH Radiotherapy News & Research Publications

General Reviews

Ultra-high dose rate electron beams and the FLASH effect: From preclinical evidence to a new radiotherapy paradigm Schüler E, Acharya M, Montay-Gruel P, et al. · Med Phys · 2022
Technological Basis for Clinical Trials in FLASH Radiation Therapy: A Review Wu Y, No H, Breitkreutz DY, Mascia AE, Moeckli R, Bourhis J, Schüler E, Maxim PG, Loo BW. . Applied Radiation Oncology. 2021 July; 10(2):6-14
Understanding high-dose, ultra-high dose rate, and spatially fractionated radiation therapy Griffin, R. J. et al. · Int J Radiat Oncol Biol Phys · 2020
Ultra-high dose rate (FLASH) radiotherapy: Silver bullet or fool’s gold? Wilson, J. D. et al. · Frontiers in Oncology · 2020
Physics and biology of ultrahigh dose-rate (FLASH) radiotherapy: a topical review Esplen, N. M. et al. · Physics in Medicine and Biology · 2020
Novel radiation therapy paradigms and immunomodulation: Heresies and hope Dutt, S., Ahmed, M. M., Loo, B. W., Jr, & Strober, S · Seminars in Radiation Oncology · 2020
Flash Radiotherapy is (Finally) on the Way Massachusetts General Hospital · Proto Magazine · 2020
PHASER linac will translate FLASH radiotherapy to the clinic Freeman, T · Physics World · 2019
FLASH radiotherapy: Newsflash or flash in the pan? Maxim, P. G., Keall, P., & Cai, J · Medical Physics · 2019

Flash Radiation Biology

Real-time optical oximetry during FLASH radiotherapy using a phosphorescent nanoprobe Ha B, Liang K, Liu C, et al. · Radiother Oncol · 2022
Design and validation of a dosimetric comparison scheme tailored for ultra-high dose-rate electron beams to support multicenter FLASH preclinical studies. Jorge PG, Melemenidis S, Grilj V, Buchillier T, Manjappa R, Viswanathan V, Gondré M, Vozenin MC, Germond JF, Bochud F, Moeckli R, Limoli C, Skinner L, No HJ, Wu YF, Surucu M, Yu AS, Lau B, Wang J, Schüler E, Bush K, Graves EE, Maxim PG, Loo BW Jr, Bailat C. Radiother Oncol. 2022 Oct;175:203-209. doi: 10.1016/j.radonc.2022.08.023
Design and validation of a dosimetric comparison scheme tailored for ultra-high dose-rate electron beams... Jorge PG, Melemenidis S, Grilj V, et al. · Radiother Oncol · 2022
Bayesian optimization to design a novel x-ray shaping device Whelan B, Trovati S, Wang J, et al. · Med Phys · 2022
Abdominopelvic FLASH Irradiation Improves PD-1 Immune Checkpoint Inhibition in Preclinical Models of Ovarian Cancer Eggold JT, Chow S, Melemenidis S, et al. · Mol Cancer Ther · 2022
Multicellular Spheroids as In Vitro Models of Oxygen Depletion During FLASH Irradiation Khan S, Bassenne M, Wang J, et al. · Int J Radiat Oncol Biol Phys · 2021
Effects of Ultra-high doserate FLASH Irradiation on the Tumor Microenvironment in Lewis Lung Carcinoma... Kim YE, Gwak SH, Hong BJ, et al. · Int J Radiat Oncol Biol Phys · 2021
An automated optimization strategy to design collimator geometry for small field radiation therapy systems Wang J, Wang L, Maxim PG, Loo BW Jr · Phys Med Biol · 2021
Effects of Ultra-high doserate FLASH Irradiation on the Tumor Microenvironment in Lewis Lung Carcinoma: Role of Myosin Light Chain. Kim YE, Gwak SH, Hong BJ, Oh JM, Choi HS, Kim MS, Oh D, Lartey FM, Rafat M, Schüler E, Kim HS, von Eyben R, Weissman IL, Koch CJ, Maxim PG, Loo BW Jr, Ahn GO. Int J Radiat Oncol Biol Phys. 2021 Apr 1;109(5):1440-1453. doi: 10.1016/j.ijrobp.2020.11.012
FLASH irradiation results in reduced severe skin toxicity compared to conventional-dose-rate irradiation Soto, L. A. et al. · Radiation Research · 2020
Evaluating the reproducibility of mouse anatomy under rotation in a custom immobilization device for conformal FLASH radiotherapy Ko, R. B. et al. · Radiation Research · 2020
Reduced cognitive deficits after FLASH irradiation of whole mouse brain are associated with less hippocampal... Simmons, D. A. et al. · Radiotherapy and Oncology · 2019
PHASER: A platform for clinical translation of FLASH cancer radiotherapy Maxim, P. G., Tantawi, S. G., & Loo, B. W., Jr · Radiotherapy and Oncology · 2019
FLASH irradiation enhances the therapeutic index of abdominal radiotherapy for the treatment of ovarian cancer Levy, K. et al. · bioRxiv · 2019
Conical beam geometry intensity-modulated radiation therapy Schüler, E., Wang, L., Loo, B. W., Jr, & Maxim, P. G · Physics in Medicine and Biology · 2019
Very high-energy electron (VHEE) beams in radiation therapy: treatment plan comparison between VHEE, VMAT, and PPBS Schüler, E., Eriksson, K., Hynning, E., et al. · Medical Physics · 2017
Thermal limits on MV x-ray production by bremsstrahlung targets in the context of novel linear accelerators Wang, J., Trovati, S., Borchard, P. M., et al. · Medical Physics · 2017
Experimental platform for ultra-high dose rate FLASH irradiation of small animals using a clinical linear accelerator Schüler, E., Trovati, S., King, G., et al. · Int J Radiat Oncol Biol Phys · 2017
Assessment of the quality of very high-energy electron radiotherapy planning Palma, B. et al. · Radiotherapy and Oncology · 2016
Treatment planning for radiotherapy with very high-energy electron beams and comparison of VHEE and VMAT plans Bazalova-Carter, M. et al. · Medical Physics · 2015
Optimization of an on-board imaging system for extremely rapid radiation therapy Cherry Kemmerling, E. M., Wu, M., Yang, H., et al. · Medical Physics · 2015
Comparison of film measurements and Monte Carlo simulations of dose delivered with very high-energy electron beams... Bazalova-Carter, M. et al. · Medical Physics · 2015

Phaser Technology Development

Bayesian optimization to design a novel x-ray shaping device. Whelan B, Trovati S, Wang J, Fahrig R, Maxim PG, Hanuka A, Shumail M, Tantawi S, Merrick J, Perl J, Keall P, Loo BW Jr. Med Phys. 2022 Dec;49(12):7623-7637. doi: 10.1002/mp.15887
An automated optimization strategy to design collimator geometry for small field radiation therapy systems. Wang J, Wang L, Maxim PG, Loo BW Jr. Phys Med Biol. 2021 Apr 6;66(7). doi: 10.1088/1361-6560/abeba9
Novel radiation therapy paradigms and immunomodulation: Heresies and hope Dutt, S., Ahmed, M. M., Loo, B. W., Jr, & Strober, S · Seminars in Radiation Oncology · 2020
https://doi.org/10.1667/RADE-20-00069.1 Breitkreutz, D. Y., Shumail, M., Bush, K. K., Tantawi, S. G., Maxim, P. G., & Loo, B. W., Jr, (2020). Initial steps towards a clinical FLASH radiotherapy system: Pediatric whole brain irradiation with 40 MeV electrons at FLASH dose rates. Radiation Research, 10.1667/RADE-20-00069.1. Advance online publication
PHASER: A platform for clinical translation of FLASH cancer radiotherapy Maxim, P. G., Tantawi, S. G., & Loo, B. W., Jr · Radiotherapy and Oncology · 2019
Conical beam geometry intensity-modulated radiation therapy Schüler, E., Wang, L., Loo, B. W., Jr, & Maxim, P. G · Physics in Medicine and Biology · 2019
Very high-energy electron (VHEE) beams in radiation therapy: treatment plan comparison between VHEE, VMAT, and PPBS Schüler, E., Eriksson, K., Hynning, E., et al. · Medical Physics · 2017
Thermal limits on MV x-ray production by bremsstrahlung targets in the context of novel linear accelerators Wang, J., Trovati, S., Borchard, P. M., et al. · Medical Physics · 2017
Assessment of the quality of very high-energy electron radiotherapy planning Palma, B. et al. · Radiotherapy and Oncology · 2016
Treatment planning for radiotherapy with very high-energy electron beams and comparison of VHEE and VMAT plans Bazalova-Carter, M. et al. · Medical Physics · 2015
Optimization of an on-board imaging system for extremely rapid radiation therapy Cherry Kemmerling, E. M., Wu, M., Yang, H., et al. · Medical Physics · 2015
Comparison of film measurements and Monte Carlo simulations of dose delivered with very high-energy electron beams... Bazalova-Carter, M. et al. · Medical Physics · 2015

Core Accelerator And Rf Power Research

Design and demonstration of a distributed-coupling linear accelerator structure Tantawi, S. G., Nasr, M., Li, Z., et al. · Physical Review Accelerators and Beams, 23(9) · 2020
Development for a supercompact X-band pulse compression system and its application at SLAC Wang, J. W., Tantawi, S. G., Xu, C., et al. · Physical Review Accelerators and Beams, 20(11) · 2017
Compact RF polarizer and its application to pulse compression systems Franzi, M., Wang, J., Dolgashev, V., & Tantawi, S. G · Physical Review Accelerators and Beams, 19 · 2016
High-power multimode X-band RF pulse compression system for future linear colliders Tantawi, S. G., Nantista, C. D., Dolgashev, V. A., et al. · PRST-AB, 8(4) · 2005
Multimoded RF delay line distribution system for the Next Linear Collider Tantawi, S. G., Nantista, C., Kroll, N., et al. · PRST-AB, 5(3) · 2002
A compact, planar, eight-port waveguide power divider/combiner: the cross potent superhybrid Nantista, C., & Tantawi, S. G · IEEE Microwave and Guided Wave Letters, 10 · 2000

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